Louisville
LOU · ACC · 8-4 · 2025
| Week | Opponent | Result |
|---|---|---|
| Week 1 | vsEastern Kentucky | W 51-17 |
| Week 2 | vs James Madison | W 28-14 |
| Week 3 | BYE | – |
| Week 4 | vs Bowling Green | W 40-17 |
| Week 5 | @ Pittsburgh | W 34-27 |
| Week 6 | vs Virginia | L 27-30 |
| Week 7 | BYE | – |
| Week 8 | @ Miami | W 24-21 |
| Week 9 | vs Boston College | W 38-24 |
| Week 10 | @ Virginia Tech | W 28-16 |
| Week 11 | vs California | L 26-29 |
| Week 12 | vs Clemson | L 19-20 |
| Week 13 | @ SMU | L 6-38 |
| Week 14 | vs Kentucky | W 41-0 |
| Week 15 | BYE | – |
| Week 16 | BYE | – |